Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
Joint Authors
Leyva-Cobián, Francisco
Fariñas, M.-Carmen
Sánchez-Velasco, Pablo
Ausín, Fernando
Guerrero-Alonso, M.-Ángeles
Ocejo-Vinyals, J.-Gonzalo
Lavín-Alconero, Lucía
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mannose-binding lectin is a central molecule of the innate immune system.
Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis.
However, contradictory results among different populations have been reported, resulting in no convincing evidence of association between mannose-binding lectin 2 and susceptibility to tuberculosis.
For this reason, we conducted a study in a well genetically conserved Spanish population in order to shed light on this controversial association.
We analysed the six promoter and structural mannose-binding lectin 2 gene variants in 107 patients with pulmonary tuberculosis and 441 healthy controls.
Only D variant and HYPD haplotype were significantly more frequents in controls which would indicate that this allele could confer protection against pulmonary tuberculosis, but this difference disappeared after statistical correction.
Neither the rest of alleles nor the haplotypes were significantly associated with the disease.
These results would indicate that mannose-binding lectin promoter polymorphisms and gene variants would not be associated with an increased risk to pulmonary tuberculosis.
Despite the slight trend of the D allele and HYPD haplotype in conferring protection against pulmonary tuberculosis, susceptibility to this disease would probably be due to other genetic factors, at least in our population.
American Psychological Association (APA)
Ocejo-Vinyals, J.-Gonzalo& Lavín-Alconero, Lucía& Sánchez-Velasco, Pablo& Guerrero-Alonso, M.-Ángeles& Ausín, Fernando& Fariñas, M.-Carmen…[et al.]. 2012. Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain). Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473953
Modern Language Association (MLA)
Ocejo-Vinyals, J.-Gonzalo…[et al.]. Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain). Pulmonary Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-473953
American Medical Association (AMA)
Ocejo-Vinyals, J.-Gonzalo& Lavín-Alconero, Lucía& Sánchez-Velasco, Pablo& Guerrero-Alonso, M.-Ángeles& Ausín, Fernando& Fariñas, M.-Carmen…[et al.]. Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain). Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473953