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Inflammation but Not Endothelial Dysfunction Is Associated with the Severity of Coronary Artery Disease in Dyslipidemic Subjects
Joint Authors
Luengas, Carlos
Rueda-Clausen, Christian F.
Cachofeiro, Victoria
López-Jaramillo, Patricio
Oubiña, Maria del Pilar
Lahera, Vicente
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Endothelial dysfunction and inflammation play a key role in the development of atherosclerosis.
The present study evaluated endothelial function, inflammatory parameters, and carotid intima-media thickness (IMT) in dyslipidemic patients with or without coronary artery disease (CAD).
Methods.
Metabolic profile and inflammatory parameters were determined in dyslipidemic patients with (+CAD, n=33) and without (−CAD, n=69) symptomatic CAD.
Endothelial function was evaluated by flow mediated dilatation (FMD) and plasma concentration of nitrites and nitrates.
Carotid IMT was measured by ultrasound.
Results.
No significant differences were observed in anthropometric hemodynamic or metabolic parameters between the groups.
After adjusting by age and medication usage, some inflammatory markers were significantly higher in +CAD; however no significant differences in FMD or plasma levels of nitrites were observed.
Conclusions.
In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.
American Psychological Association (APA)
Rueda-Clausen, Christian F.& López-Jaramillo, Patricio& Luengas, Carlos& Oubiña, Maria del Pilar& Cachofeiro, Victoria& Lahera, Vicente. 2009. Inflammation but Not Endothelial Dysfunction Is Associated with the Severity of Coronary Artery Disease in Dyslipidemic Subjects. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-473957
Modern Language Association (MLA)
Rueda-Clausen, Christian F.…[et al.]. Inflammation but Not Endothelial Dysfunction Is Associated with the Severity of Coronary Artery Disease in Dyslipidemic Subjects. Mediators of Inflammation No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-473957
American Medical Association (AMA)
Rueda-Clausen, Christian F.& López-Jaramillo, Patricio& Luengas, Carlos& Oubiña, Maria del Pilar& Cachofeiro, Victoria& Lahera, Vicente. Inflammation but Not Endothelial Dysfunction Is Associated with the Severity of Coronary Artery Disease in Dyslipidemic Subjects. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-473957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473957