A Putative Case of Methotrexate-Related Lymphoma : Clinical Course and PETCT Findings

Abstract EN

Patients with autoimmune conditions develop lymphoproliferative disorders (LPDs) at a higher frequency than normal both in association with and independent of Methotrexate (MTX).

We describe a case of MTX-associated lymphoma in a patient with psoriasis on long-standing MTX.

The case is notable for the initial tumor burden, the dramatic disappearance of the PET-CT findings on discontinuation of MTX, and the subsequent early regrowth of disease.

Our case report is illustrative of an MTX-related NHL in an autoimmune patient.

Conclusion.

Withdrawal of MTX in a patient with lymphoma is reasonable before initiating chemotherapy, but observation for early regrowth of disease is necessary.