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Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats
Joint Authors
Pérez-Abud, Rocío
Wangensteen, Rosemary
Cruz, Antonio
Vargas, Miguel Ángel
Quesada, Andrés
Rodríguez-Gómez, Isabel
Moreno, Juan Manuel
Osuna, Antonio
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effects of clofibrate on the hemodynamic and renal manifestations of increased saline intake were analyzed.
Four groups of male Wistar rats were treated for five weeks: control, clofibrate (240 mg/kg/day), salt (2% via drinking water), and salt+clofibrate.
Body weight, systolic blood pressure (SBP), and heart rate (HR) were recorded weekly.
Finally, SBP, HR, and morphologic, metabolic, plasma, and renal variables were measured.
Salt increased SBP, HR, urinary isoprostanes, NOx, ET, vasopressin and proteinuria and reduced plasma free T4 (FT4) and tissue FT4 and FT3 versus control rats.
Clofibrate prevented the increase in SBP produced by salt administration, reduced the sodium balance, and further reduced plasma and tissue thyroid hormone levels.
However, clofibrate did not modify the relative cardiac mass, NOx, urinary ET, and vasopressin of saline-loaded rats.
In conclusion, chronic clofibrate administration prevented the blood pressure elevation of salt-loaded rats by decreasing sodium balance and reducing thyroid hormone levels.
American Psychological Association (APA)
Cruz, Antonio& Rodríguez-Gómez, Isabel& Pérez-Abud, Rocío& Vargas, Miguel Ángel& Wangensteen, Rosemary& Quesada, Andrés…[et al.]. 2010. Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473992
Modern Language Association (MLA)
Cruz, Antonio…[et al.]. Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-473992
American Medical Association (AMA)
Cruz, Antonio& Rodríguez-Gómez, Isabel& Pérez-Abud, Rocío& Vargas, Miguel Ángel& Wangensteen, Rosemary& Quesada, Andrés…[et al.]. Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473992