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Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-Targeted Therapy
Joint Authors
Abdel-Wahab, Omar
Fathi, Amir T.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In the recent years, the discovery of a series of mutations in patients with myeloid malignancies has provided insight into the pathogenesis of myelodysplastic syndromes (MDSs), myeloproliferative neoplasms (MPNs), and acute myeloid leukemia (AML).
Among these alterations have been mutations in genes, such as IDH1/2, TET2, DNMT3A, and EZH2, which appear to affect DNA and/or histone lysine methylation.
Large clinical correlative studies are beginning to decipher the clinical importance, prevalence, and potential prognostic significance of these mutations.
Additionally, burgeoning insight into the role of epigenetics in the pathogenesis of myeloid malignancies has prompted increased interest in development of novel therapies which target DNA and histone posttranslational modifications.
DNA demethylating agents have been demonstrated to be clinically active in a subset of patients with MDS and AML and are used extensively.
However, newer, more specific agents which alter DNA and histone modification are under preclinical study and development and are likely to expand our therapeutic options for these diseases in the near future.
Here, we review the current understanding of the clinical importance of these newly discovered mutations in AML and MDS patients.
We also discuss exciting developments in DNA methyltransferase inhibitor strategies and the prospect of novel histone lysine methyltransferase inhibitors.
American Psychological Association (APA)
Fathi, Amir T.& Abdel-Wahab, Omar. 2011. Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-Targeted Therapy. Advances in Hematology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-474001
Modern Language Association (MLA)
Fathi, Amir T.& Abdel-Wahab, Omar. Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-Targeted Therapy. Advances in Hematology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-474001
American Medical Association (AMA)
Fathi, Amir T.& Abdel-Wahab, Omar. Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-Targeted Therapy. Advances in Hematology. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-474001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474001