Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor
Joint Authors
Willard, Francis S.
Sloop, Kyle W.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The glucagon-like peptide-1 (GLP-1) receptor is one of the best validated therapeutic targets for the treatment of type 2 diabetes mellitus (T2DM).
Over several years, the accumulation of basic, translational, and clinical research helped define the physiologic roles of GLP-1 and its receptor in regulating glucose homeostasis and energy metabolism.
These efforts provided much of the foundation for pharmaceutical development of the GLP-1 receptor peptide agonists, exenatide and liraglutide, as novel medicines for patients suffering from T2DM.
Now, much attention is focused on better understanding the molecular mechanisms involved in ligand induced signaling of the GLP-1 receptor.
For example, advancements in biophysical and structural biology techniques are being applied in attempts to more precisely determine ligand binding and receptor occupancy characteristics at the atomic level.
These efforts should better inform three-dimensional modeling of the GLP-1 receptor that will help inspire more rational approaches to identify and optimize small molecule agonists or allosteric modulators targeting the GLP-1 receptor.
This article reviews GLP-1 receptor physiology with an emphasis on GLP-1 induced signaling mechanisms in order to highlight new molecular strategies that help determine desired pharmacologic characteristics for guiding development of future nonpeptide GLP-1 receptor activators.
American Psychological Association (APA)
Willard, Francis S.& Sloop, Kyle W.. 2012. Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-474095
Modern Language Association (MLA)
Willard, Francis S.& Sloop, Kyle W.. Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor. Experimental Diabetes Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-474095
American Medical Association (AMA)
Willard, Francis S.& Sloop, Kyle W.. Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-474095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474095