![](/images/graphics-bg.png)
Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function
Joint Authors
Liu, Zun-Jing
Liu, Wei
Wang, Yu
Jiao, Jing-Song
Liu, Lei
Xiao, Cheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cerebral ischemia is the most common cerebrovascular disease worldwide.
Recent studies have demonstrated that curcumin had beneficial effect to attenuate cerebral ischemic injury.
However, it is unclear how curcumin protects against cerebral ischemic injury.
In the present study, using rat middle cerebral artery occlusion model, we found that curcumin was a potent PPARγ agonist in that it upregulated PPARγ expression and PPARγ-PPRE binding activity.
Administration of curcumin markedly decreased the infarct volume, improved neurological deficits, and reduced neuronal damage of rats.
In addition, curcumin suppressed neuroinflammatory response by decreasing inflammatory mediators, such as IL-1β, TNF-α, PGE2, NO, COX-2, and iNOS induced by cerebral ischemia of rats.
Furthermore, curcumin suppressed IκB degradation that was caused by cerebral ischemia.
The present data also showed that PPARγ interacted with NF-κB-p65 and thus inhibited NF-κB activation.
All the above protective effects of curcumin on cerebral ischemic injury were markedly attenuated by GW9662, an inhibitor of PPARγ.
Our results as described above suggested that PPARγ induced by curcumin may play a critical role in protecting against brain injury through suppression of inflammatory response.
It also highlights the potential of curcumin as a therapeutic agent against cerebral ischemia.
American Psychological Association (APA)
Liu, Zun-Jing& Liu, Wei& Liu, Lei& Xiao, Cheng& Wang, Yu& Jiao, Jing-Song. 2013. Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474100
Modern Language Association (MLA)
Liu, Zun-Jing…[et al.]. Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-474100
American Medical Association (AMA)
Liu, Zun-Jing& Liu, Wei& Liu, Lei& Xiao, Cheng& Wang, Yu& Jiao, Jing-Song. Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474100