Predictors of Time to RelapseRecurrence after Electroconvulsive Therapy in Patients with Major Depressive Disorder : A Population-Based Cohort Study

Abstract EN

Objective.

The aim of the study is to define predictors of relapse/recurrence after electroconvulsive therapy, ECT, for patients with major depressive disorder.

Methods.

A study of all patients (n=486) treated by means of ECT for major depressive disorder was performed.

The data were derived from a regional quality register in Sweden.

Psychiatric hospitalisation or suicide was used as a marker for relapse/recurrence.

Results.

The relapse/recurrence rate within one year after ECT was 34%.

Factors associated with increased risk of relapse/recurrence included comorbid substance dependence and treatment with benzodiazepines or antipsychotics during the follow-up period.

Conclusions.

Within the first years after ECT, relapses/recurrences leading to hospitalisation or suicide are common.

Treatment with lithium might be beneficial, while benzodiazepines, antipsychotics, or continuation ECT does not seem to significantly reduce the risk of relapse/recurrence.