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Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication
Joint Authors
Sugarbaker, Paul H.
Stuart, O. Anthony
Eger, Christopher
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
In patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space.
We monitored the intrapleural and plasma levels of mitomycin C and doxorubicin by HPLC assay in order to determine the pharmacokinetic behavior of this intracavitary use of chemotherapy.
Our results showed a persistent high concentration of intrapleural drug as compared to plasma concentrations.
The increased exposure for mitomycin C was 96, and the increased exposure for doxorubicin was 241.
When the clearance of chemotherapy from the thoracic cavity was compared to clearance from the abdomen and pelvis, there was a considerably more rapid clearance from the abdomen as compared to the thorax.
The pharmacologic study of intrapleural chemotherapy in these patients provides a strong pharmacologic rationale for regional chemotherapy in this group of patients.
American Psychological Association (APA)
Sugarbaker, Paul H.& Stuart, O. Anthony& Eger, Christopher. 2012. Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-474111
Modern Language Association (MLA)
Sugarbaker, Paul H.…[et al.]. Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication. Gastroenterology Research and Practice No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-474111
American Medical Association (AMA)
Sugarbaker, Paul H.& Stuart, O. Anthony& Eger, Christopher. Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-474111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474111