Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept
Joint Authors
Ometto, Francesca
Punzi, Leonardo
Botsios, Costantino
Raffeiner, Bernd
Bernardi, Livio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Ankylosing spondylitis (AS) is presented with axial and peripheral articular involvement.
Uveitis is a severe and rather specific manifestation of AS.
Biologics targeting tumor necrosis factor (TNF) α are effective on both articular and ocular manifestations of disease.
The occurrence of uveitis in patients that never had eye involvement or the relapse of uveitis is described during anti-TNFα treatment.
The frequency of these events is slightly higher during therapy with etanercept.
The available TNFα blockers show different pharmacokinetics and pharmacodynamics yielding different biological effects.
There is an ongoing debate whether uveitis during anti-TNFα has to be considered as paradoxical effect or an inadequate response to therapy.
Here, we present a case report and review what the evidences for the two hypotheses are.
American Psychological Association (APA)
Raffeiner, Bernd& Ometto, Francesca& Bernardi, Livio& Botsios, Costantino& Punzi, Leonardo. 2014. Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-474121
Modern Language Association (MLA)
Raffeiner, Bernd…[et al.]. Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept. Case Reports in Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-474121
American Medical Association (AMA)
Raffeiner, Bernd& Ometto, Francesca& Bernardi, Livio& Botsios, Costantino& Punzi, Leonardo. Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-474121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474121