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The Role of Testosterone in the Etiology and Treatment of Obesity, the Metabolic Syndrome, and Diabetes Mellitus Type 2
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity has become a major health problem.
Testosterone plays a significant role in obesity, glucose homeostasis, and lipid metabolism.
The metabolic syndrome is a clustering of risk factors predisposing to diabetes mellitus type 2, atherosclerosis, and cardiovascular morbidity and mortality.
The main components of the syndrome are visceral obesity, insulin resistance, glucose intolerance, raised blood pressure and dyslipidemia (elevated triglycerides, low levels of high-density lipoprotein cholesterol), and a proinflammatory and thrombogenic state.
Cross-sectional epidemiological studies have reported a direct correlation between plasma testosterone and insulin sensitivity, and low testosterone levels are associated with an increased risk of type 2 diabetes mellitus, dramatically illustrated by androgen deprivation in men with prostate carcinoma.
Lower total testosterone and sex hormone-binding globulin (SHBG) predict a higher incidence of the metabolic syndrome.
Administration of testosterone to hypogonadal men reverses part of the unfavorable risk profile for the development of diabetes and atherosclerosis.
American Psychological Association (APA)
Saad, Farid& Gooren, Louis J.. 2010. The Role of Testosterone in the Etiology and Treatment of Obesity, the Metabolic Syndrome, and Diabetes Mellitus Type 2. Journal of Obesity،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474145
Modern Language Association (MLA)
Saad, Farid& Gooren, Louis J.. The Role of Testosterone in the Etiology and Treatment of Obesity, the Metabolic Syndrome, and Diabetes Mellitus Type 2. Journal of Obesity No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-474145
American Medical Association (AMA)
Saad, Farid& Gooren, Louis J.. The Role of Testosterone in the Etiology and Treatment of Obesity, the Metabolic Syndrome, and Diabetes Mellitus Type 2. Journal of Obesity. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474145