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Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes
Joint Authors
Di Fenza, Raffaele
Petrelli, Alessandra
Gatti, Francesca
Carvello, Michele
Fiorina, Paolo
Secchi, Antonio
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bone-marrow-derived cells-mediated postnatal vasculogenesis has been reported as the main responsible for the regulation of vascular homeostasis in adults.
Since their discovery, endothelial progenitor cells have been depicted as mediators of postnatal vasculogenesis for their peculiar phenotype (partially staminal and partially endothelial), their ability to differentiate in endothelial cell line and to be incorporated into the vessels wall during ischemia/damage.
Diabetes mellitus, a condition characterized by cardiovascular disease, nephropathy, and micro- and macroangiopathy, showed a dysfunction of endothelial progenitor cells.
Herein, we review the mechanisms involved in diabetes-related dysfunction of endothelial progenitor cells, highlighting how hyperglycemia affects the different steps of endothelial progenitor cells lifetime (i.e., bone marrow mobilization, trafficking into the bloodstream, differentiation in endothelial cells, and homing in damaged tissues/organs).
Finally, we review preclinical and clinical strategies that aim to revert diabetes-induced dysfunction of endothelial progenitor cells as a means of finding new strategies to prevent diabetic complications.
American Psychological Association (APA)
Petrelli, Alessandra& Di Fenza, Raffaele& Carvello, Michele& Gatti, Francesca& Secchi, Antonio& Fiorina, Paolo. 2012. Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474174
Modern Language Association (MLA)
Petrelli, Alessandra…[et al.]. Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes. Experimental Diabetes Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-474174
American Medical Association (AMA)
Petrelli, Alessandra& Di Fenza, Raffaele& Carvello, Michele& Gatti, Francesca& Secchi, Antonio& Fiorina, Paolo. Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474174