Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract : Implication for the Development of Pharmacological Treatments
Joint Authors
Vejux, Anne
Samadi, Mohammad
Lizard, Gérard
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The development of cataract is associated with some lipid changes in human lens fibers, especially with increased accumulation and redistribution of cholesterol inside these cells.
Some direct and indirect lines of evidence, also suggest an involvement of cholesterol oxide derivatives (also named oxysterols) in the development of cataract.
Oxysterol formation can result either from nonenzymatic or enzymatic processes, and some oxysterols can induce a wide range of cytotoxic effects (overproduction of reactive oxygen species (ROS); phospholipidosis) which might contribute to the initiation and progression of cataract.
Thus, the conception of molecules capable of regulating cholesterol homeostasia and oxysterol levels in human lens fibers can have some interests and constitute an alternative to surgery at least at early stages of the disease.
American Psychological Association (APA)
Vejux, Anne& Samadi, Mohammad& Lizard, Gérard. 2011. Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract : Implication for the Development of Pharmacological Treatments. Journal of Ophthalmology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474189
Modern Language Association (MLA)
Vejux, Anne…[et al.]. Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract : Implication for the Development of Pharmacological Treatments. Journal of Ophthalmology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-474189
American Medical Association (AMA)
Vejux, Anne& Samadi, Mohammad& Lizard, Gérard. Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract : Implication for the Development of Pharmacological Treatments. Journal of Ophthalmology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474189