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Associations of Prenatal Growth with Metabolic Syndrome, Insulin Resistance, and Nutritional Status in Chilean Children
Joint Authors
Castillo, Oscar
Pacheco, Paz
Mardones, Francisco
Villarroel, Luis
Eriksson, Johan G.
Dominguez, Angelica
Barja, Salesa
Arnaiz, Pilar
Farías-Jofré, Marcelo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
The association of prenatal growth with nutritional status, metabolic syndrome (MS), and insulin resistance (IR) was studied in school-age children.
Methods.
A retrospective cohort study was designed linking present data of children with perinatal records.
3325 subjects were enrolled.
Anthropometry, blood pressure (BP), and pubertal status were assessed.
Blood lipids, glucose, and insulin were measured.
Linear associations were assessed using the Cochran-Armitage test.
Odds ratios and nonlinear associations were computed.
Results.
3290 children (52% females, mean age of 11.4 ± 1 years) were analyzed.
Prevalence of obesity, stunting, MS, and IR was 16.0%, 3.6%, 7.3%, and 25.5%, respectively.
The strongest positive association was between birth weight (BW) and obesity (OR 2.97 (95% CI 2.01–4.40) at BW ≥ 4,000 g compared to BW 2,500–2,999).
The strongest inverse association was between birth length (BL) and stunting (OR 8.70 (95% CI 3.66–20.67) at BL < 48 cm compared to BL 52-53 cm).
A U-shaped association between BL and BP ≥ 90th percentile was observed.
Significant ORs were also found for MS and IR.
Adjustments for present fat mass increased or maintained the most prenatal growth influences.
Conclusions.
Prenatal growth influences MS, IR, and nutritional status.
Prenatal growth was more important than present body composition in determining these outcomes.
American Psychological Association (APA)
Mardones, Francisco& Arnaiz, Pilar& Pacheco, Paz& Dominguez, Angelica& Villarroel, Luis& Eriksson, Johan G.…[et al.]. 2014. Associations of Prenatal Growth with Metabolic Syndrome, Insulin Resistance, and Nutritional Status in Chilean Children. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-474197
Modern Language Association (MLA)
Mardones, Francisco…[et al.]. Associations of Prenatal Growth with Metabolic Syndrome, Insulin Resistance, and Nutritional Status in Chilean Children. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-474197
American Medical Association (AMA)
Mardones, Francisco& Arnaiz, Pilar& Pacheco, Paz& Dominguez, Angelica& Villarroel, Luis& Eriksson, Johan G.…[et al.]. Associations of Prenatal Growth with Metabolic Syndrome, Insulin Resistance, and Nutritional Status in Chilean Children. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-474197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474197