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Parvovirus B19 Associated Hepatitis
Joint Authors
Chowdhury, Ashok
Rastogi, Archana
Bihari, Chhagan
Rangegowda, Devraj
Saxena, Priyanka
Gupta, Nalini
Sarin, Shiv Kumar
Source
Hepatitis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parvovirus B19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them.
Parvovirus B19 hepatitis associated aplastic anemia and its coinfection with other hepatotropic viruses are relatively underrecognized, and there is sufficient evidence in the literature suggesting that B19 infections can cause a spectrum of liver diseases from elevation of transaminases to acute hepatitis to fulminant liver failure and even chronic hepatitis.
It can also cause fatal macrophage activation syndrome and fibrosing cholestatic hepatitis.
Parvovirus B19 is an erythrovirus that can only be replicate in pronormoblasts and hepatocytes, and other cells which have globosides and glycosphingolipids in their membrane can also be affected by direct virus injury due to nonstructural protein 1 persistence and indirectly by immune mediated injury.
The virus infection is suspected in bone marrow aspiration in cases with sudden drop of hemoglobin and onset of transient aplastic anemia in immunosuppressed or immunocompetent patients and is confirmed either by IgM and IgG positive serology, PCR analysis, and in situ hybridization in biopsy specimens or by application of both.
There is no specific treatment for parvovirus B19 related liver diseases, but triple therapy regimen may be effective consisting of immunoglobulin, dehydrohydrocortisone, and cyclosporine.
American Psychological Association (APA)
Bihari, Chhagan& Rastogi, Archana& Saxena, Priyanka& Rangegowda, Devraj& Chowdhury, Ashok& Gupta, Nalini…[et al.]. 2013. Parvovirus B19 Associated Hepatitis. Hepatitis Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474199
Modern Language Association (MLA)
Bihari, Chhagan…[et al.]. Parvovirus B19 Associated Hepatitis. Hepatitis Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-474199
American Medical Association (AMA)
Bihari, Chhagan& Rastogi, Archana& Saxena, Priyanka& Rangegowda, Devraj& Chowdhury, Ashok& Gupta, Nalini…[et al.]. Parvovirus B19 Associated Hepatitis. Hepatitis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-474199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474199