IgG4 Cholangiopathy
Joint Authors
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
IgG4 cholangiopathy can involve any level of the biliary tree which exhibits sclerosing cholangitis or pseudotumorous hilar lesions.
Most cases are associated with autoimmune pancreatitis, an important diagnostic clue.
Without autoimmune pancreatitis, however, the diagnosis of IgG4-cholangiopathy is challenging.
Indeed such cases have been treated surgically.
IgG4-cholangiopathy should be diagnosed based on serological examinations including serum IgG4 concentrations, radiological features, and histological evidence of IgG4+ plasma cell infiltration.
Steroid therapy is very effective even at disease relapse.
A Th2-dominant immune response or the activation of regulatory T cells seems to be involved in the underlying immune reaction.
It is still unknown why IgG4 levels are specifically elevated in patients with this disease.
IgG4 might be secondarily overexpressed by Th2 or regulatory cytokines given the lack of evidence that IgG4 is an autoantibody.
American Psychological Association (APA)
Zen, Yoh& Nakanuma, Yasuni. 2011. IgG4 Cholangiopathy. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-474226
Modern Language Association (MLA)
Zen, Yoh& Nakanuma, Yasuni. IgG4 Cholangiopathy. International Journal of Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-474226
American Medical Association (AMA)
Zen, Yoh& Nakanuma, Yasuni. IgG4 Cholangiopathy. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-474226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474226