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Investigating Topological and Functional Features of Multimodular Proteins
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To generate functional modules as functionally and structurally cohesive formations in protein interaction networks (PINs) constitutes an important step towards understanding how modules communicate on a higher level of the PIN organisation that underlies cell functionality.
However, we need to understand how individual modules communicate and are organized into the higher-order structure(s) of the PIN organization that underlies cell functionality.
In an attempt to contribute to this understanding, we make an assumption that the proteins reappearing in several modules, termed here as multimodular proteins (MMPs), may be useful in building higher-order structure(s) as they may constitute communication points between different modules.
In this paper, we investigate common properties shared by these proteins and compare them with the properties of so-called single-modular proteins (SMPs) by analyzing three aspects: functional aspect, that is, annotation of the proteins, topological aspect that is betweenness centrality of the proteins, and lethality.
Furthermore, we investigate the interconnectivity role of some proteins that are identified as functionally and topologically important.
American Psychological Association (APA)
Lubovac, Zelmina. 2009. Investigating Topological and Functional Features of Multimodular Proteins. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-474232
Modern Language Association (MLA)
Lubovac, Zelmina. Investigating Topological and Functional Features of Multimodular Proteins. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-474232
American Medical Association (AMA)
Lubovac, Zelmina. Investigating Topological and Functional Features of Multimodular Proteins. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-474232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474232