Fatty Acids in Energy Metabolism of the Central Nervous System
Joint Authors
Vavilin, Valentin
Orynbayeva, Zulfiya
Lyakhovich, Vyacheslav
Panov, Alexander
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
In this review, we analyze the current hypotheses regarding energy metabolism in the neurons and astroglia.
Recently, it was shown that up to 20% of the total brain’s energy is provided by mitochondrial oxidation of fatty acids.
However, the existing hypotheses consider glucose, or its derivative lactate, as the only main energy substrate for the brain.
Astroglia metabolically supports the neurons by providing lactate as a substrate for neuronal mitochondria.
In addition, a significant amount of neuromediators, glutamate and GABA, is transported into neurons and also serves as substrates for mitochondria.
Thus, neuronal mitochondria may simultaneously oxidize several substrates.
Astrocytes have to replenish the pool of neuromediators by synthesis de novo, which requires large amounts of energy.
In this review, we made an attempt to reconcile β-oxidation of fatty acids by astrocytic mitochondria with the existing hypothesis on regulation of aerobic glycolysis.
We suggest that, under condition of neuronal excitation, both metabolic pathways may exist simultaneously.
We provide experimental evidence that isolated neuronal mitochondria may oxidize palmitoyl carnitine in the presence of other mitochondrial substrates.
We also suggest that variations in the brain mitochondrial metabolic phenotype may be associated with different mtDNA haplogroups.
American Psychological Association (APA)
Panov, Alexander& Orynbayeva, Zulfiya& Vavilin, Valentin& Lyakhovich, Vyacheslav. 2014. Fatty Acids in Energy Metabolism of the Central Nervous System. BioMed Research International،Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-474234
Modern Language Association (MLA)
Panov, Alexander…[et al.]. Fatty Acids in Energy Metabolism of the Central Nervous System. BioMed Research International No. 2014 (2014), pp.1-22.
https://search.emarefa.net/detail/BIM-474234
American Medical Association (AMA)
Panov, Alexander& Orynbayeva, Zulfiya& Vavilin, Valentin& Lyakhovich, Vyacheslav. Fatty Acids in Energy Metabolism of the Central Nervous System. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-474234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474234