Microsatellite Instability in Sarcoma : Fact or Fiction?
Joint Authors
Schiffman, Joshua D.
Randall, Rl. Tx.
Monument, Michael J.
Lessnick, Stephen L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Microsatellite instability (MSI) is a unique molecular abnormality, indicative of a deficient DNA mismatch repair (MMR) system.
Described and characterized in the colorectal cancer literature, the MSI-positive phenotype is predictive of disease susceptibility, pathogenesis, and prognosis.
The clinical relevance of MSI in colorectal cancer has inspired similar inquisition within the sarcoma literature, although unfortunately, with very heterogeneous results.
Evolving detection techniques, ill-defined sarcoma-specific microsatellite loci and small study numbers have hampered succinct conclusions.
The literature does suggest that MSI in sarcoma is observed at a frequency similar to that of sporadic colorectal cancers, although there is little evidence to suggest that MSI-positive tumors share distinct biological attributes.
Emerging evidence in Ewing sarcoma has demonstrated an intriguing mechanistic role of microsatellite DNA in the activation of key EWS/FLI-target genes.
These findings provide an alternative perspective to the biological implications of microsatellite instability in sarcoma and warrant further investigation using sophisticated detection techniques, sensitive microsatellite loci, and appropriately powered study designs.
American Psychological Association (APA)
Monument, Michael J.& Lessnick, Stephen L.& Schiffman, Joshua D.& Randall, Rl. Tx.. 2012. Microsatellite Instability in Sarcoma : Fact or Fiction?. ISRN Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474294
Modern Language Association (MLA)
Monument, Michael J.…[et al.]. Microsatellite Instability in Sarcoma : Fact or Fiction?. ISRN Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-474294
American Medical Association (AMA)
Monument, Michael J.& Lessnick, Stephen L.& Schiffman, Joshua D.& Randall, Rl. Tx.. Microsatellite Instability in Sarcoma : Fact or Fiction?. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474294