Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis
Joint Authors
Zhang, Ming
Dang, Jingxia
Zhang, Qiuli
Jin, Jiaoting
Bai, Lijun
Mao, Cuiping
Niu, Chen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Conflicting findings have been reported regarding the lateralized brain abnormality in patients with amyotrophic lateral sclerosis (ALS).
In this study, we aimed to investigate the probable lateralization of gray matter (GM) atrophy in ALS patients.
We focused on the relationship between the asymmetry in decreased GM volume and the side of disease onset in patients with limb-onset.
Structural imaging evaluation of normalized atrophy (SIENAX) and voxel-based morphometry (VBM) were used to assess differences in global and local brain regions in patients with heterogeneous body onset and subgroups with different side of limb-onset.
We found global brain atrophy and GM losses in the frontal and parietal areas in each patient group as well as left predominant GM losses in the total cohort.
The intriguing findings in subgroup analyses demonstrated that the motor cortex in the contralateral hemisphere of the initially involved limb was most affected.
We also found that regional brain atrophy was related to disease progression rate.
Our observations suggested that side of limb-onset can predict laterality of GM loss in ALS patients and disease progression correlates with the extent of cortical abnormality.
American Psychological Association (APA)
Zhang, Qiuli& Mao, Cuiping& Jin, Jiaoting& Niu, Chen& Bai, Lijun& Dang, Jingxia…[et al.]. 2014. Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-474309
Modern Language Association (MLA)
Zhang, Qiuli…[et al.]. Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-474309
American Medical Association (AMA)
Zhang, Qiuli& Mao, Cuiping& Jin, Jiaoting& Niu, Chen& Bai, Lijun& Dang, Jingxia…[et al.]. Side of Limb-Onset Predicts Laterality of Gray Matter Loss in Amyotrophic Lateral Sclerosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-474309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474309