Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm
Joint Authors
Woods, Gary M.
Guinipero, Terri
Kahwash, Samir B.
Bajwa, Rajinder P. S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations.
Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor prognosis.
Although the evolution of a JAK2-V617F+ MPN to a mixed-lineage leukemia has been reported in the pediatric population, no evolutions into sAML have been described.
We present a case of a one-year-old girl diagnosed with JAK2-V617F+ MPN with evolution into sAML.
Despite initial morphologic remission, she eventually relapsed and succumbed to her disease.
American Psychological Association (APA)
Woods, Gary M.& Bajwa, Rajinder P. S.& Kahwash, Samir B.& Guinipero, Terri. 2014. Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-474316
Modern Language Association (MLA)
Woods, Gary M.…[et al.]. Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm. Case Reports in Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-474316
American Medical Association (AMA)
Woods, Gary M.& Bajwa, Rajinder P. S.& Kahwash, Samir B.& Guinipero, Terri. Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-474316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474316
