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Emerging Molecular Targets for Brain Repair after Stroke
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The field of neuroprotection generated consistent preclinical findings of mechanisms of cell death but these failed to be translated into clinics.
The approaches that combine the modulation of the inhibitory environment together with the promotion of intrinsic axonal outgrowth needs further work before combined therapeutic strategies will be transferable to clinic trials.
It is likely that only when some answers have been found to these issues will our therapeutic efforts meet our expectations.
Stroke is a clinically heterogeneous disease and combinatorial treatments require much greater work in pharmacological and toxicological testing.
Advances in genetics and results of the Whole Human Genome Project (HGP) provided new unknown information in relation to stroke.
Genetic factors are not the only determinants of responses to some diseases.
It was recognized early on that “epigenetic” factors were major players in the aetiology and progression of many diseases like stroke.
The major players are microRNAs that represent the best-characterized subclass of noncoding RNAs.
Epigenetic mechanisms convert environmental conditions and physiological stresses into long-term changes in gene expression and translation.
Epigenetics in stroke are in their infancy but offer great promise for better understanding of stroke pathology and the potential viability of new strategies for its treatment.
American Psychological Association (APA)
Krupinski, Jerzy& Slevin, Mark. 2013. Emerging Molecular Targets for Brain Repair after Stroke. Stroke Research and Treatment،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-474319
Modern Language Association (MLA)
Krupinski, Jerzy& Slevin, Mark. Emerging Molecular Targets for Brain Repair after Stroke. Stroke Research and Treatment No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-474319
American Medical Association (AMA)
Krupinski, Jerzy& Slevin, Mark. Emerging Molecular Targets for Brain Repair after Stroke. Stroke Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-474319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474319