Nonmotor Symptoms in Patients with PARK2 Mutations
Joint Authors
Yoritaka, Asako
Yoshino, Hiroyo
Inoue, Yuichi
Hattori, Nobutaka
Shimo, Yumi
Shimo, Yasushi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Decreased 123I-meta-iodobenzylguanidine (MIBG) uptake in MIBG myocardial scintigraphy, olfactory dysfunction, and rapid eye movement (REM) sleep behavior disorder (RBD) are considered useful early indicators of Parkinson disease.
We investigated whether patients with PARK2 mutations exhibited myocardial sympathetic abnormalities using MIBG scintigraphy, olfactory dysfunction using the Sniffin’ Sticks olfactory test, and RBD using polysomnography.
None of the examined patients had RBD, and all except 1 patient exhibited an increase in the olfactory threshold.
Moreover, one of the oldest patients exhibited impairment in identification and discrimination.
Of 12 patients with PARK2 mutations, 4 patients, who were older than patients without abnormal uptake, exhibited decreased MIBG uptake.
The results obtained in this study suggest that some patients with PARK2 mutations have increased thresholds of olfactory function and myocardial sympathetic dysfunction as nonmotor symptoms.
American Psychological Association (APA)
Yoritaka, Asako& Shimo, Yumi& Shimo, Yasushi& Inoue, Yuichi& Yoshino, Hiroyo& Hattori, Nobutaka. 2011. Nonmotor Symptoms in Patients with PARK2 Mutations. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-474354
Modern Language Association (MLA)
Yoritaka, Asako…[et al.]. Nonmotor Symptoms in Patients with PARK2 Mutations. Journal of Nanomaterials No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-474354
American Medical Association (AMA)
Yoritaka, Asako& Shimo, Yumi& Shimo, Yasushi& Inoue, Yuichi& Yoshino, Hiroyo& Hattori, Nobutaka. Nonmotor Symptoms in Patients with PARK2 Mutations. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-474354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474354