![](/images/graphics-bg.png)
Heme Oxygenase-1 : A Critical Link between Iron Metabolism, Erythropoiesis, and Development
Joint Authors
Midwinter, Robyn G.
Stocker, Roland
Fraser, Stuart T.
Berger, Birgit S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The first mature cells to arise in the developing mammalian embryo belong to the erythroid lineage.
This highlights the immediacy of the need for red blood cells during embryogenesis and for survival.
Linked with this pressure is the necessity of the embryo to obtain and transport iron, synthesize hemoglobin, and then dispose of the potentially toxic heme via the stress-induced protein heme oxygenase-1 (HO-1, encoded by Hmox1 in the mouse).
Null mutation of Hmox1 results in significant embryonic mortality as well as anemia and defective iron recycling.
Here, we discuss the interrelated nature of this critical enzyme with iron trafficking, erythroid cell function, and embryonic survival.
American Psychological Association (APA)
Fraser, Stuart T.& Midwinter, Robyn G.& Berger, Birgit S.& Stocker, Roland. 2011. Heme Oxygenase-1 : A Critical Link between Iron Metabolism, Erythropoiesis, and Development. Advances in Hematology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474359
Modern Language Association (MLA)
Fraser, Stuart T.…[et al.]. Heme Oxygenase-1 : A Critical Link between Iron Metabolism, Erythropoiesis, and Development. Advances in Hematology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-474359
American Medical Association (AMA)
Fraser, Stuart T.& Midwinter, Robyn G.& Berger, Birgit S.& Stocker, Roland. Heme Oxygenase-1 : A Critical Link between Iron Metabolism, Erythropoiesis, and Development. Advances in Hematology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474359