Production of Adenosine by Ectonucleotidases : A Key Factor in Tumor Immunoescape
Joint Authors
Ghiringhelli, François
Rébé, Cédric
Chalmin, Fanny
Bruchard, Mélanie
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It is now well known that tumor immunosurveillance contributes to the control of cancer growth.
Many mechanisms can be used by cancer cells to avoid the antitumor immune response.
One such mechanism relies on the capacity of cancer cells or more generally of the tumor microenvironment to generate adenosine, a major molecule involved in antitumor T cell response suppression.
Adenosine is generated by the dephosphorylation of extracellular ATP released by dying tumor cells.
The conversion of ATP into adenosine is mediated by ectonucleotidase molecules, namely, CD73 and CD39.
These molecules are frequently expressed in the tumor bed by a wide range of cells including tumor cells, regulatory T cells, Th17 cells, myeloid cells, and stromal cells.
Recent evidence suggests that targeting adenosine by inhibiting ectonucleotidases may restore the resident antitumor immune response or enhance the efficacy of antitumor therapies.
This paper will underline the impact of adenosine and ectonucleotidases on the antitumor response.
American Psychological Association (APA)
Ghiringhelli, François& Bruchard, Mélanie& Chalmin, Fanny& Rébé, Cédric. 2012. Production of Adenosine by Ectonucleotidases : A Key Factor in Tumor Immunoescape. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474360
Modern Language Association (MLA)
Ghiringhelli, François…[et al.]. Production of Adenosine by Ectonucleotidases : A Key Factor in Tumor Immunoescape. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-474360
American Medical Association (AMA)
Ghiringhelli, François& Bruchard, Mélanie& Chalmin, Fanny& Rébé, Cédric. Production of Adenosine by Ectonucleotidases : A Key Factor in Tumor Immunoescape. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474360