Potential Therapeutic Use of PPARγ-Programed Human Monocyte-Derived Dendritic Cells in Cancer Vaccination Therapy
Joint Authors
Gyöngyösi, Adrienn
Nagy, László
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Dendritic cells (DCs) can regulate all elements of the immune system, and therefore are an ideal target for vaccination.
During the last two decades, as a result of extensive research, DCs became the primary target of antitumor vaccination as well.
A critical issue of antitumor vaccination is the phenotype of the dendritic cell used.
It has been recently shown that several nuclear hormone receptors, and amongst them the lipid-activated nuclear receptor and peroxisome proliferator-activated receptor gamma (PPARγ), have important roles in effecting the immunophenotype of human dendritic cells.
It regulates primarily lipid metabolism and via this it influences the immunophenotype of DCs by altering lipid antigen uptake, presentation, and also other immune functions.
In this review, we summarize the principles of antitumor vaccination strategies and present our hypothesis on how PPARγ-regulated processes might be involved and could be exploited in the design of vaccination strategies.
American Psychological Association (APA)
Gyöngyösi, Adrienn& Nagy, László. 2008. Potential Therapeutic Use of PPARγ-Programed Human Monocyte-Derived Dendritic Cells in Cancer Vaccination Therapy. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-474369
Modern Language Association (MLA)
Gyöngyösi, Adrienn& Nagy, László. Potential Therapeutic Use of PPARγ-Programed Human Monocyte-Derived Dendritic Cells in Cancer Vaccination Therapy. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-474369
American Medical Association (AMA)
Gyöngyösi, Adrienn& Nagy, László. Potential Therapeutic Use of PPARγ-Programed Human Monocyte-Derived Dendritic Cells in Cancer Vaccination Therapy. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-474369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474369