Membrane Transporters as Mediators of Cisplatin Effects and Side Effects
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-25
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Transporters are important mediators of specific cellular uptake and thus, not only for effects, but also for side effects, metabolism, and excretion of many drugs such as cisplatin.
Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity.
For this reason, other platinum derivatives, such as carboplatin and oxaliplatin, with less toxicity but still with antitumoral action have been developed.
Several transporters, which are expressed on the cell membranes, have been associated with cisplatin transport across the plasma membrane and across the cell: the copper transporter 1 (Ctr1), the copper transporter 2 (Ctr2), the P-type copper-transporting ATPases ATP7A and ATP7B, the organic cation transporter 2 (OCT2), and the multidrug extrusion transporter 1 (MATE1).
Some of these transporters are also able to accept other platinum derivatives as substrate.
Since membrane transporters display a specific tissue distribution, they can be important molecules that mediate the entry of platinum derivatives in target and also nontarget cells possibly mediating specific effects and side effects of the chemotherapeutic drug.
This paper summarizes the literature on toxicities of cisplatin compared to that of carboplatin and oxaliplatin and the interaction of these platinum derivatives with membrane transporters.
American Psychological Association (APA)
Ciarimboli, Giuliano. 2012. Membrane Transporters as Mediators of Cisplatin Effects and Side Effects. Scientifica،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-474372
Modern Language Association (MLA)
Ciarimboli, Giuliano. Membrane Transporters as Mediators of Cisplatin Effects and Side Effects. Scientifica No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-474372
American Medical Association (AMA)
Ciarimboli, Giuliano. Membrane Transporters as Mediators of Cisplatin Effects and Side Effects. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-474372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474372