LncRNAs : New Players in Apoptosis Control
Joint Authors
Rossi, Marianna Nicoletta
Antonangeli, Fabrizio
Source
International Journal of Cell Biology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community.
Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration.
Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis.
Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli.
In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation.
We discuss the new perspectives of using lncRNAs as targets of anticancer drugs.
Finally, considering that lncRNA levels have been reported to have a correlation with specific cancer types, we argue the possibility of using lncRNAs as tumor biomarkers.
American Psychological Association (APA)
Rossi, Marianna Nicoletta& Antonangeli, Fabrizio. 2014. LncRNAs : New Players in Apoptosis Control. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-474377
Modern Language Association (MLA)
Rossi, Marianna Nicoletta& Antonangeli, Fabrizio. LncRNAs : New Players in Apoptosis Control. International Journal of Cell Biology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-474377
American Medical Association (AMA)
Rossi, Marianna Nicoletta& Antonangeli, Fabrizio. LncRNAs : New Players in Apoptosis Control. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-474377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474377