![](/images/graphics-bg.png)
HIV Infection and TLR Signalling in the Liver
Joint Authors
Visvanathan, Kumar
Lewin, Sharon R.
Crane, Megan
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Despite the availability of effective combination antiretroviral therapy (cART), liver disease is one of the leading causes of morbidity and mortality in Human Immunodeficiency Virus (HIV)-infected individuals, specifically, in the presence of viral hepatitis coinfection.
HIV, a single stranded RNA virus, can bind to and activate both Toll-like receptor (TLR)7 and TLR8 in circulating blood mononuclear cells, but little is known about the effect of HIV on TLRs expressed in the liver.
HIV can directly infect cells of the liver and HIV-mediated depletion of CD4+ T-cells in the gastrointestinal tract (GI tract) results in increased circulating lipopolysaccharide (LPS), both of which may impact on TLR signaling in the liver and subsequent liver disease progression.
The potential direct and indirect effects of HIV on TLR signaling in the liver will be explored in this paper.
American Psychological Association (APA)
Crane, Megan& Visvanathan, Kumar& Lewin, Sharon R.. 2012. HIV Infection and TLR Signalling in the Liver. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-474384
Modern Language Association (MLA)
Crane, Megan…[et al.]. HIV Infection and TLR Signalling in the Liver. Gastroenterology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-474384
American Medical Association (AMA)
Crane, Megan& Visvanathan, Kumar& Lewin, Sharon R.. HIV Infection and TLR Signalling in the Liver. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-474384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474384