Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models
Joint Authors
Akkol, Esra Küpeli
Pesin, Ipek
Koca, Ufuk
Yilmazer, Demet
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine.
To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achillea biebersteinii.
Linear incision by using tensiometer and circular excision wound models were employed on mice and rats.
The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol.
The n-hexane extract treated groups of animals showed 84.2% contraction, which was close to contraction value of the reference drug Madecassol (100%).
On the other hand the same extract on incision wound model demonstrated a significant increase (40.1%) in wound tensile strength as compared to other groups.
The results of histoptological examination supported the outcome of linear incision and circular excision wound models as well.
The experimental data demonstrated that A.
biebersteinii displayed remarkable wound healing activity.
American Psychological Association (APA)
Akkol, Esra Küpeli& Koca, Ufuk& Pesin, Ipek& Yilmazer, Demet. 2011. Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-474402
Modern Language Association (MLA)
Akkol, Esra Küpeli…[et al.]. Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-474402
American Medical Association (AMA)
Akkol, Esra Küpeli& Koca, Ufuk& Pesin, Ipek& Yilmazer, Demet. Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-474402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474402