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Oxidative Stress Is Involved in the Pathogenesis of Keshan Disease (an Endemic Dilated Cardiomyopathy) in China
Joint Authors
Yang, Liu
Fu, Wenqi
Pei, Junrui
Liu, Yang
Zhang, Zhiyi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress and selenoprotein deficiency are thought to be associated with the pathogenesis of Keshan disease (KD).
However, to our knowledge, the level of oxidative stress and expression of selenoproteins have not been investigated in the myocardium of patients with KD.
In this study, 8-hydroxy-2-deoxy guanosine (8-OH-dG), a marker of oxidative stress, was used to assess the level of oxidative stress, and thioredoxin reductase 1 (TrxR1) and glutathione peroxidase 1 (GPx1) were assessed to reflect the level of selenoproteins.
Myocardial samples from 8 patients with KD and 9 non-KD patients (controls) were immunohistochemically stained for 8-OH-dG, TrxR1, and GPx1.
The staining intensities were subsequently quantified using Olympus Image-Pro Plus 6.0 software.
The data showed that the positive rate of 8-OH-dG expression in myocardial nuclei was higher in the KD group (68.6%) than that in the control group (2.4%).
In addition, a positive correlation between the positive rate of 8-OH-dG and the degree of myocardial damage was observed in the KD group.
The distribution of TrxR1 and GPx-1 was not associated with the distribution of myocardial damage.
The expression of these two selenoproteins was higher in the control group than that in the KD group.
Our study represents the first report on the expression profiles of oxidative stress and selenoproteins in the myocardium of patients with KD.
The level of oxidative stress significantly increased and was positively correlated with the degree of myocardial damage in patients with KD.
The selenoproteins, TrxR1 and GPx1, may have a role in the pathogenesis of KD.
American Psychological Association (APA)
Pei, Junrui& Fu, Wenqi& Yang, Liu& Zhang, Zhiyi& Liu, Yang. 2013. Oxidative Stress Is Involved in the Pathogenesis of Keshan Disease (an Endemic Dilated Cardiomyopathy) in China. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-474414
Modern Language Association (MLA)
Pei, Junrui…[et al.]. Oxidative Stress Is Involved in the Pathogenesis of Keshan Disease (an Endemic Dilated Cardiomyopathy) in China. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-474414
American Medical Association (AMA)
Pei, Junrui& Fu, Wenqi& Yang, Liu& Zhang, Zhiyi& Liu, Yang. Oxidative Stress Is Involved in the Pathogenesis of Keshan Disease (an Endemic Dilated Cardiomyopathy) in China. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-474414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474414