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Potential Role of Drebrin A, an F-Actin Binding Protein, in Reactive Synaptic Plasticity after Pilocarpine-Induced Seizures : Functional Implications in Epilepsy
Author
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Several neurological disorders characterized by cognitive deficits, including Alzheimer's disease, down syndrome, and epilepsy exhibit abnormal spine density and/or morphology.
Actin-based cytoskeleton network dynamics is critical for the regulation of spine morphology and synaptic function.
In this paper, I consider the functions of drebrin A in cell shaping, spine plasticity, and synaptic function.
Developmentally regulated brain protein (drebrin A) is one of the most abundant neuron-specific binding proteins of F-actin and its expression is increased in parallel with synapse formation.
Drebrin A is particularly concentrated in dendritic spines receiving excitatory inputs.
Our recent findings point to a critical role of DA in dendritic spine structural integrity and stabilization, likely via regulation of actin cytoskeleton dynamics, and glutamatergic synaptic function that underlies the development of spontaneous recurrent seizures in pilocarpine-treated animals.
Further research into this area may provide useful insights into the pathology of status epilepticus and epileptogenic mechanisms and ultimately may provide the basis for future treatment options.
American Psychological Association (APA)
Ferhat, Lotfi. 2012. Potential Role of Drebrin A, an F-Actin Binding Protein, in Reactive Synaptic Plasticity after Pilocarpine-Induced Seizures : Functional Implications in Epilepsy. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-474424
Modern Language Association (MLA)
Ferhat, Lotfi. Potential Role of Drebrin A, an F-Actin Binding Protein, in Reactive Synaptic Plasticity after Pilocarpine-Induced Seizures : Functional Implications in Epilepsy. International Journal of Cell Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-474424
American Medical Association (AMA)
Ferhat, Lotfi. Potential Role of Drebrin A, an F-Actin Binding Protein, in Reactive Synaptic Plasticity after Pilocarpine-Induced Seizures : Functional Implications in Epilepsy. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-474424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474424