MicroRNA Gene Dosage Alterations and Drug Response in Lung Cancer
Joint Authors
Chari, Raj
Alvarez, Carlos E.
Enfield, Katey S. S.
Pikor, Larissa A.
Lam, Stephen
Stewart, Greg L.
Lam, Wan L.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chemotherapy resistance is a key contributor to the dismal prognoses for lung cancer patients.
While the majority of studies have focused on sequence mutations and expression changes in protein-coding genes, recent reports have suggested that microRNA (miRNA) expression changes also play an influential role in chemotherapy response.
However, the role of genetic alterations at miRNA loci in the context of chemotherapy response has yet to be investigated.
In this study, we demonstrate the application of an integrative, multidimensional approach in order to identify miRNAs that are associated with chemotherapeutic resistance and sensitivity utilizing publicly available drug response, miRNA loci copy number, miRNA expression, and mRNA expression data from independent resources.
By instigating a logical stepwise strategy, we have identified specific miRNAs that are associated with resistance to several chemotherapeutic agents and provide a proof of principle demonstration of how these various databases may be exploited to derive relevant pharmacogenomic results.
American Psychological Association (APA)
Enfield, Katey S. S.& Stewart, Greg L.& Pikor, Larissa A.& Alvarez, Carlos E.& Lam, Stephen& Lam, Wan L.…[et al.]. 2011. MicroRNA Gene Dosage Alterations and Drug Response in Lung Cancer. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-474446
Modern Language Association (MLA)
Enfield, Katey S. S.…[et al.]. MicroRNA Gene Dosage Alterations and Drug Response in Lung Cancer. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-474446
American Medical Association (AMA)
Enfield, Katey S. S.& Stewart, Greg L.& Pikor, Larissa A.& Alvarez, Carlos E.& Lam, Stephen& Lam, Wan L.…[et al.]. MicroRNA Gene Dosage Alterations and Drug Response in Lung Cancer. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-474446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474446