Serotonin 5-HT2A Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases
Author
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There are high levels of comorbidity between neuropsychiatric and cardiovascular disorders.
A key molecule central to both cognitive and cardiovascular function is the molecule serotonin.
In the brain, serotonin modulates neuronal activity and is actively involved in mediating many cognitive functions and behaviors.
In the periphery, serotonin is involved in vasoconstriction, inflammation, and cell growth, among other processes.
It is hypothesized that one component of the serotonin system, the 5-HT2A receptor, is a common and contributing factor underlying aspects of the comorbidity between neuropsychiatric and cardiovascular disorders.
Within the brain this receptor participates in processes such as cognition and working memory, been implicated in effective disorders such as schizophrenia, and mediate the primary effects of hallucinogenic drugs.
In the periphery, 5-HT2A receptors have been linked to vasoconstriction and hypertension, and to inflammatory processes that can lead to atherosclerosis.
American Psychological Association (APA)
Nichols, Charles D.. 2009. Serotonin 5-HT2A Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-474491
Modern Language Association (MLA)
Nichols, Charles D.. Serotonin 5-HT2A Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-474491
American Medical Association (AMA)
Nichols, Charles D.. Serotonin 5-HT2A Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-474491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474491