Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus
Joint Authors
Antushevich, Hanna
Herman, Anna
Herman, Andrzej Przemysław
Krawczyńska, Agata
Bochenek, Joanna
Tomaszewska-Zaremba, Dorota
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The study was designed to determine the effects of peripheral injection of SB203580 on the synthesis of interleukin- (IL-) 1β, IL-6, and tumor necrosis factor (TNF) α in the hypothalamus of ewes during prolonged inflammation.
Inflammation was induced by the administration of lipopolysaccharide (LPS) (400 ng/kg) over 7 days.
SB203580 is a selective ATP-competitive inhibitor of the p38 mitogen-activated protein kinase (MAPK), which is involved in the regulation of proinflammatory cytokines IL-1β, IL-6 and TNFα synthesis.
Intravenous injection of SB203580 successfully inhibited (P<0.01) synthesis of IL-1β and reduced (P<0.01) the production of IL-6 in the hypothalamus.
The p38 MAPK inhibitor decreased (P<0.01) gene expression of TNFα but its effect was not observed at the level of TNFα protein synthesis.
SB203580 also reduced (P<0.01) LPS-stimulated IL-1 receptor type 1 gene expression.
The conclusion that inhibition of p38 MAPK blocks LPS-induced proinflammatory cytokine synthesis seems to initiate new perspectives in the treatment of chronic inflammatory diseases also within the central nervous system.
However, potential proinflammatory effects of SB203580 treatment suggest that all therapies using p38 MAPK inhibitors should be introduced very carefully with analysis of all expected and unexpected consequences of treatment.
American Psychological Association (APA)
Herman, Andrzej Przemysław& Krawczyńska, Agata& Bochenek, Joanna& Antushevich, Hanna& Herman, Anna& Tomaszewska-Zaremba, Dorota. 2014. Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-474496
Modern Language Association (MLA)
Herman, Andrzej Przemysław…[et al.]. Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-474496
American Medical Association (AMA)
Herman, Andrzej Przemysław& Krawczyńska, Agata& Bochenek, Joanna& Antushevich, Hanna& Herman, Anna& Tomaszewska-Zaremba, Dorota. Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-474496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474496