Emulsion Electrospinning as an Approach to Fabricate PLGAChitosan Nanofibers for Biomedical Applications
Joint Authors
Wickham, Abeni
Ajalloueian, Fatemeh
Arpanaei, Ayyoob
Donzel-Gargand, Olivier
Tavanai, Hossein
Hilborn, Jöns
Leifer, Klaus
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Novel nanofibers from blends of polylactic-co-glycolic acid (PLGA) and chitosan have been produced through an emulsion electrospinning process.
The spinning solution employed polyvinyl alcohol (PVA) as the emulsifier.
PVA was extracted from the electrospun nanofibers, resulting in a final scaffold consisting of a blend of PLGA and chitosan.
The fraction of chitosan in the final electrospun mat was adjusted from 0 to 33%.
Analyses by scanning and transmission electron microscopy show uniform nanofibers with homogenous distribution of PLGA and chitosan in their cross section.
Infrared spectroscopy verifies that electrospun mats contain both PLGA and chitosan.
Moreover, contact angle measurements show that the electrospun PLGA/chitosan mats are more hydrophilic than electrospun mats of pure PLGA.
Tensile strengths of 4.94 MPa and 4.21 MPa for PLGA/chitosan in dry and wet conditions, respectively, illustrate that the polyblend mats of PLGA/chitosan are strong enough for many biomedical applications.
Cell culture studies suggest that PLGA/chitosan nanofibers promote fibroblast attachment and proliferation compared to PLGA membranes.
It can be assumed that the nanofibrous composite scaffold of PLGA/chitosan could be potentially used for skin tissue reconstruction.
American Psychological Association (APA)
Ajalloueian, Fatemeh& Tavanai, Hossein& Hilborn, Jöns& Donzel-Gargand, Olivier& Leifer, Klaus& Wickham, Abeni…[et al.]. 2014. Emulsion Electrospinning as an Approach to Fabricate PLGAChitosan Nanofibers for Biomedical Applications. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-474511
Modern Language Association (MLA)
Ajalloueian, Fatemeh…[et al.]. Emulsion Electrospinning as an Approach to Fabricate PLGAChitosan Nanofibers for Biomedical Applications. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-474511
American Medical Association (AMA)
Ajalloueian, Fatemeh& Tavanai, Hossein& Hilborn, Jöns& Donzel-Gargand, Olivier& Leifer, Klaus& Wickham, Abeni…[et al.]. Emulsion Electrospinning as an Approach to Fabricate PLGAChitosan Nanofibers for Biomedical Applications. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-474511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474511