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Pure Red Cell Aplasia and Lymphoproliferative Disorders : An Infrequent Association
Joint Authors
Ioannidou-Papagiannaki, Elizabeth
Klonizakis, Philippos
Diamantidis, Michael D.
Haralambidou-Vranitsa, Styliani
Klonizakis, Ioannis
Vlachaki, Euthymia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Pure red cell aplasia (PRCA) is a rare bone marrow failure syndrome defined by a progressive normocytic anaemia and reticulocytopenia without leukocytopenia and thrombocytopenia.
Secondary PRCA can be associated with various haematological disorders, such as chronic lymphocytic leukaemia (CLL) or non-Hodgkin lymphoma (NHL).
The aim of the present review is to investigate the infrequent association between PRCA and lymphoproliferative disorders.
PRCA might precede the appearance of lymphoma, may present simultaneously with the lymphoid neoplastic disease, or might appear following the lymphomatic disorder.
Possible pathophysiological molecular mechanisms to explain the rare association between PRCA and lymphoproliferative disorders are reported.
Most cases of PRCA are presumed to be autoimmune mediated by antibodies against either erythroblasts or erythropoietin, by T-cells secreting factors selectively inhibiting erythroid colonies in the bone marrow or by NK cells directly lysing erythroblasts.
Finally, focus is given to the therapeutical approach, as several treatment regimens have failed for PRCA.
Immunosuppressive therapy and/or chemotherapy are effective for improving anaemia in the majority of patients with lymphoma-associated PRCA.
Further investigation is required to define the pathophysiology of PRCA at a molecular level and to provide convincing evidence why it might appear as a rare complication of lymphoproliferative disorders.
American Psychological Association (APA)
Vlachaki, Euthymia& Diamantidis, Michael D.& Klonizakis, Philippos& Haralambidou-Vranitsa, Styliani& Ioannidou-Papagiannaki, Elizabeth& Klonizakis, Ioannis. 2012. Pure Red Cell Aplasia and Lymphoproliferative Disorders : An Infrequent Association. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474515
Modern Language Association (MLA)
Vlachaki, Euthymia…[et al.]. Pure Red Cell Aplasia and Lymphoproliferative Disorders : An Infrequent Association. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-474515
American Medical Association (AMA)
Vlachaki, Euthymia& Diamantidis, Michael D.& Klonizakis, Philippos& Haralambidou-Vranitsa, Styliani& Ioannidou-Papagiannaki, Elizabeth& Klonizakis, Ioannis. Pure Red Cell Aplasia and Lymphoproliferative Disorders : An Infrequent Association. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474515