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Identification of Modules Related to Programmed Cell Death in CHD Based on EHEN
Joint Authors
Li, Wan
Du, Youwen
Feng, Chenchen
Liu, Zhe
Miao, Zhengqiang
He, Weiming
Hou, Min
Li, Danbin
Jia, Xu
Lv, Junjie
Chen, Lina
He, Yuehan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The formation and death of macrophages and foam cells are one of the major factors that cause coronary heart disease (CHD).
In our study, based on the Edinburgh Human Metabolic Network (EHMN) metabolic network, we built an enzyme network which was constructed by enzymes (nodes) and reactions (edges) called the Edinburgh Human Enzyme Network (EHEN).
By integrating the subcellular location information for the reactions and refining the protein-reaction relationships based on the location information, we proposed a computational approach to select modules related to programmed cell death.
The identified module was in the EHEN-mitochondria (EHEN-M) and was confirmed to be related to programmed cell death, CHD pathogenesis, and lipid metabolism in the literature.
We expected this method could analyze CHD better and more comprehensively from the point of programmed cell death in subnetworks.
American Psychological Association (APA)
Jia, Xu& Li, Wan& Miao, Zhengqiang& Feng, Chenchen& Liu, Zhe& He, Yuehan…[et al.]. 2014. Identification of Modules Related to Programmed Cell Death in CHD Based on EHEN. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-474522
Modern Language Association (MLA)
Jia, Xu…[et al.]. Identification of Modules Related to Programmed Cell Death in CHD Based on EHEN. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-474522
American Medical Association (AMA)
Jia, Xu& Li, Wan& Miao, Zhengqiang& Feng, Chenchen& Liu, Zhe& He, Yuehan…[et al.]. Identification of Modules Related to Programmed Cell Death in CHD Based on EHEN. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-474522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474522