Databases and Bioinformatics Tools for the Study of DNA Repair
Joint Authors
Bujnicki, Janusz M.
Milanowska, Kaja
Rother, Kristian
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
DNA is continuously exposed to many different damaging agents such as environmental chemicals, UV light, ionizing radiation, and reactive cellular metabolites.
DNA lesions can result in different phenotypical consequences ranging from a number of diseases, including cancer, to cellular malfunction, cell death, or aging.
To counteract the deleterious effects of DNA damage, cells have developed various repair systems, including biochemical pathways responsible for the removal of single-strand lesions such as base excision repair (BER) and nucleotide excision repair (NER) or specialized polymerases temporarily taking over lesion-arrested DNA polymerases during the S phase in translesion synthesis (TLS).
There are also other mechanisms of DNA repair such as homologous recombination repair (HRR), nonhomologous end-joining repair (NHEJ), or DNA damage response system (DDR).
This paper reviews bioinformatics resources specialized in disseminating information about DNA repair pathways, proteins involved in repair mechanisms, damaging agents, and DNA lesions.
American Psychological Association (APA)
Milanowska, Kaja& Rother, Kristian& Bujnicki, Janusz M.. 2011. Databases and Bioinformatics Tools for the Study of DNA Repair. Molecular Biology International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-474547
Modern Language Association (MLA)
Milanowska, Kaja…[et al.]. Databases and Bioinformatics Tools for the Study of DNA Repair. Molecular Biology International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-474547
American Medical Association (AMA)
Milanowska, Kaja& Rother, Kristian& Bujnicki, Janusz M.. Databases and Bioinformatics Tools for the Study of DNA Repair. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-474547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474547