Antiviral Treatment for Hepatitis C Virus Infection after Liver Transplantation
Joint Authors
Tamura, Sumihito
Sugawara, Yasuhiko
Kokudo, Norihiro
Source
Hepatitis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A significant proportion of patients with chronic hepatitis C virus (HCV) infection develop liver cirrhosis and complications of end-stage liver disease over two to three decades and require liver transplantation, however, reinfection is common and leads to further adverse events under immunosuppression.
Pretransplant antiviral or preemptive therapy is limited to mildly decompensated patients due to poor tolerance.
The mainstay of management represents directed antiviral therapy after evidence of recurrence of chronic hepatitis C.
Combined pegylated interferon and ribavirin therapy is the current standard treatment with sustained viral response rates of 25% to 45%.
The rate is lower than that in the immunocompetent population, partly due to the high prevalence of intolerability.
To date, there is no general consensus regarding the antiviral treatment modality, timing, or dosing for HCV in patients with advanced liver disease and after liver transplantation.
New anti-HCV drugs to delay disease progression or to enhance viral clearance are necessary.
American Psychological Association (APA)
Sugawara, Yasuhiko& Tamura, Sumihito& Kokudo, Norihiro. 2010. Antiviral Treatment for Hepatitis C Virus Infection after Liver Transplantation. Hepatitis Research and Treatment،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-474553
Modern Language Association (MLA)
Sugawara, Yasuhiko…[et al.]. Antiviral Treatment for Hepatitis C Virus Infection after Liver Transplantation. Hepatitis Research and Treatment No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-474553
American Medical Association (AMA)
Sugawara, Yasuhiko& Tamura, Sumihito& Kokudo, Norihiro. Antiviral Treatment for Hepatitis C Virus Infection after Liver Transplantation. Hepatitis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-474553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474553