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TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran : Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations
Joint Authors
Gouas, Doriane
Villar, Stéphanie
Sotoudeh, Masoud
Hainaut, Pierre
Abedi-Ardekani, Behnoush
Source
Hepatitis Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
High incidence of HCC is mostly due to the combination of two major risk factors, chronic infection with hepatitis B (HBV) and/or C (HCV) viruses and exposure to the mycotoxin aflatoxin B1, which induces a particular mutation at codon 249 in TP53 (R249S).
Eight genotypes of HBV are diversely found in high and low incidence areas.
Regardless of documented strong associations between TP53 R249S mutation and HBV genotypes B, C, A or E, there is no report of such association for genotype D despite of the presence of aflatoxin in areas with high prevalence of HBV genotype D.
In Iran, 3% of the population is chronically infected with HBV, predominantly genotype D.
Twenty-one histologically confirmed HCC cases from Iran were analyzed for TP53 R249S and HBV double mutations 1762T/1764A, hallmarks of more pathogenic forms of HBV.
We did not detect any of these mutations.
In addition, we report the only case identified so far carrying both R249S mutation and chronic HBV genotype D, a patient from The Gambia in West Africa.
This paper suggests that association between HBV genotype D and aflatoxin-induced TP53 mutation is uncommon, explaining the relatively lower incidence of HCC in areas where genotype D is highly prevalent.
American Psychological Association (APA)
Abedi-Ardekani, Behnoush& Gouas, Doriane& Villar, Stéphanie& Sotoudeh, Masoud& Hainaut, Pierre. 2011. TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran : Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations. Hepatitis Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474577
Modern Language Association (MLA)
Abedi-Ardekani, Behnoush…[et al.]. TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran : Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations. Hepatitis Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-474577
American Medical Association (AMA)
Abedi-Ardekani, Behnoush& Gouas, Doriane& Villar, Stéphanie& Sotoudeh, Masoud& Hainaut, Pierre. TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran : Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations. Hepatitis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-474577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474577