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Potential Markers for Detection and Monitoring of Ovarian Cancer
Joint Authors
Safi, Joelle
Dada, Rima
Michener, Chad
Rein, Brandon J. D.
Agarwal, Ashok
Gupta, Sajal
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This paper reviews current screening techniques as well as novel biomarkers and their potential role in early detection of ovarian cancer.
Ovarian cancer is one of the most common reproductive cancers and has the highest mortality rate amongst gynecologic cancers.
Because most ovarian cancer diagnoses occur in the late stages of the disease, five-year survival rates fall below 20%.
To improve survival rates and to lower mortality rates for ovarian cancer, improved detection at early stages of the disease is needed.
Current screening approaches include tumor markers, ultrasound, or a combination.
Efforts are underway to discover new biomarkers of ovarian cancer in order to surmount the obstacles in early-stage diagnosis.
Among serum protein markers, HE4 and mesothelin can augment CA125 detection providing higher sensitivity and specificity due to the presence of these proteins in early-stage ovarian cancer.
Detection testing that includes methylation of the MCJ gene and increased expression of vascular endothelial growth factor is correlated to poor prognosis and may predict patient survival outcome.
Detection testing of biomarkers with long-term stability and combination panels of markers, will likely lead to effective screening strategies with high specificity and sensitivity for early detection of ovarian cancer.
American Psychological Association (APA)
Rein, Brandon J. D.& Gupta, Sajal& Dada, Rima& Safi, Joelle& Michener, Chad& Agarwal, Ashok. 2011. Potential Markers for Detection and Monitoring of Ovarian Cancer. Journal of Oncology،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-474580
Modern Language Association (MLA)
Rein, Brandon J. D.…[et al.]. Potential Markers for Detection and Monitoring of Ovarian Cancer. Journal of Oncology No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-474580
American Medical Association (AMA)
Rein, Brandon J. D.& Gupta, Sajal& Dada, Rima& Safi, Joelle& Michener, Chad& Agarwal, Ashok. Potential Markers for Detection and Monitoring of Ovarian Cancer. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-474580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474580