A Human Hepatocyte-Bearing Mouse : An Animal Model to Predict Drug Metabolism and Effectiveness in Humans
Joint Authors
Yoshizato, Katsutoshi
Tateno, Chise
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Preclinical studies to predict the efficacy and safety of drugs have conventionally been conducted almost exclusively in mice and rats as rodents, despite the differences in drug metabolism between humans and rodents.
Furthermore, human (h) viruses such as hepatitis viruses do not infect the rodent liver.
A mouse bearing a liver in which the hepatocytes have been largely repopulated with h-hepatocytes would overcome some of these disadvantages.
We have established a practical, efficient, and large-scale production system for such mice.
Accumulated evidence has demonstrated that these hepatocyte-humanized mice are a useful and reliable animal model, exhibiting h-type responses in a series of in vivo drug processing (adsorption, distribution, metabolism, excretion) experiments and in the infection and propagation of hepatic viruses.
In this review, we present the current status of studies on chimeric mice and describe their usefulness in the study of peroxisome proliferator-activated receptors.
American Psychological Association (APA)
Yoshizato, Katsutoshi& Tateno, Chise. 2009. A Human Hepatocyte-Bearing Mouse : An Animal Model to Predict Drug Metabolism and Effectiveness in Humans. PPAR Research،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-474602
Modern Language Association (MLA)
Yoshizato, Katsutoshi& Tateno, Chise. A Human Hepatocyte-Bearing Mouse : An Animal Model to Predict Drug Metabolism and Effectiveness in Humans. PPAR Research No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-474602
American Medical Association (AMA)
Yoshizato, Katsutoshi& Tateno, Chise. A Human Hepatocyte-Bearing Mouse : An Animal Model to Predict Drug Metabolism and Effectiveness in Humans. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-474602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474602