NOD1-Mediated Mucosal Host Defense against Helicobacter pylori
Joint Authors
Chiba, Tsutomu
Fuss, Ivan J.
Asano, Naoki
Watanabe, Tomohiro
Kitani, Atsushi
Strober, Warren
Source
International Journal of Inflammation
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma.
Although it has been well established that persistent colonization by H.
pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th1 responses are poorly defined.
Recent studies have shown that the activation of nucleotide-binding oligomerization domain 1 (NOD1) in gastric epithelial cells plays an important role in innate immune responses against H.
pylori.
The detection of H.
pylori-derived ligands by cytosolic NOD1 induces several host defense factors, including antimicrobial peptides, cytokines, and chemokines.
In this paper, we review the molecular mechanisms by which NOD1 contributes to mucosal host defense against H.
pylori infection of the stomach.
American Psychological Association (APA)
Watanabe, Tomohiro& Asano, Naoki& Kitani, Atsushi& Fuss, Ivan J.& Chiba, Tsutomu& Strober, Warren. 2010. NOD1-Mediated Mucosal Host Defense against Helicobacter pylori. International Journal of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-474627
Modern Language Association (MLA)
Watanabe, Tomohiro…[et al.]. NOD1-Mediated Mucosal Host Defense against Helicobacter pylori. International Journal of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-474627
American Medical Association (AMA)
Watanabe, Tomohiro& Asano, Naoki& Kitani, Atsushi& Fuss, Ivan J.& Chiba, Tsutomu& Strober, Warren. NOD1-Mediated Mucosal Host Defense against Helicobacter pylori. International Journal of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-474627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474627