Pathological Scenario with the Mannose-Binding Lectin in Patients with IgA Nephropathy
Joint Authors
Tomino, Yasuhiko
Ohsawa, Isao
Ishii, Masaya
Ohi, Hiroyuki
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A deeper understanding of the mechanism of complement activation may help to elucidate the pathogenesis of IgA nephropathy (IgAN).
Traditionally, the activation of an alternative pathway (AP) has been recognized as an enhancer mechanism of glomerular damage.
This paper documents contemporary information concerning the possible pathological mechanisms of the lectin pathway (LP) in the circulation and in the glomerulus.
The circulating initiator of LP activation is not fully understood.
However, ligands for mannose-binding lectin (MBL) which are among the starter molecules of the LP are aberrant glycosylated molecules-containing immune complex.
Recent reports have focused on N-glycans on secretory IgA as a candidate ligand.
Mesangial deposits of MBL are seen in 25% of patients with IgAN.
Mesangial deposits of MBL and C4 and/or C4 breakdown products are implicated as markers for disease progression of IgAN.
On the other hand, patients with MBL deficiency tend to show better clinical presentation and lower levels of urinary protein and serum creatinine than MBL-sufficient patients.
It is now recognized that involvement of AP and LP constitutes an additional mechanism for explaining the progression of IgAN.
American Psychological Association (APA)
Ohsawa, Isao& Ishii, Masaya& Ohi, Hiroyuki& Tomino, Yasuhiko. 2012. Pathological Scenario with the Mannose-Binding Lectin in Patients with IgA Nephropathy. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-474647
Modern Language Association (MLA)
Ohsawa, Isao…[et al.]. Pathological Scenario with the Mannose-Binding Lectin in Patients with IgA Nephropathy. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-474647
American Medical Association (AMA)
Ohsawa, Isao& Ishii, Masaya& Ohi, Hiroyuki& Tomino, Yasuhiko. Pathological Scenario with the Mannose-Binding Lectin in Patients with IgA Nephropathy. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-474647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474647