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The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD
Joint Authors
Schiattarella, Antonietta
Mancini, Aldo
Tuccillo, Franca Maria
Bonelli, Patrizia
Buonaguro, Franco Maria
Borrelli, Antonella
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reactive oxygen species (ROS) are generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells.
This work describes the role of the manganese superoxide dismutase (MnSOD) as a biomarker of different human diseases and proposes a new therapeutic application for the prevention of cancer and its treatment.
The paper also describes how a new form of human MnSOD was discovered, its initial application, and its clinical potentials.
The MnSOD isolated from a human liposarcoma cell line (LSA) was able to kill cancer cells expressing estrogen receptors, but it did not have cytotoxic effects on normal cells.
Together with its oncotoxic activity, the recombinant MnSOD (rMnSOD) exerts a radioprotective effect on normal cells irradiated with X-rays.
The rMnSOD is characterized by the presence of a leader peptide, which allows the protein to enter cells: this unique property can be used in the radiodiagnosis of cancer or chemotherapy, conjugating radioactive substances or chemotherapic drugs to the leader peptide of the MnSOD.
Compared to traditional chemotherapic agents, the drugs conjugated with the leader peptide of MnSOD can selectively reach and enter cancer cells, thus reducing the side effects of traditional treatments.
American Psychological Association (APA)
Borrelli, Antonella& Schiattarella, Antonietta& Bonelli, Patrizia& Tuccillo, Franca Maria& Buonaguro, Franco Maria& Mancini, Aldo. 2014. The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-474656
Modern Language Association (MLA)
Borrelli, Antonella…[et al.]. The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-474656
American Medical Association (AMA)
Borrelli, Antonella& Schiattarella, Antonietta& Bonelli, Patrizia& Tuccillo, Franca Maria& Buonaguro, Franco Maria& Mancini, Aldo. The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-474656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474656