A Crucial Role of Bone Morphogenetic Protein Signaling in the Wound Healing Response in Acute Liver Injury Induced by Carbon Tetrachloride
Joint Authors
Sato, Kenzo
Kanai, Ayumi Miyashita
Taniguchi, Kumiko Amano
Nakanishi, Tomoko
Oumi, Nao
Yasunaga, Mayu
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Acute liver injury induced by administration of carbon tetrachloride (CCl4) has used a model of wound repair in the rat liver.
Previously, we reported transient expression of bone morphogenetic protein (Bmp) 2 or Bmp4 at 6–24 h after CCl4 treatment, suggesting a role of BMP signaling in the wound healing response in the injured liver.
In the present study, we investigated the biological meaning of the transient Bmp expression in liver injury.
Methods.
Using conditional knockout mice carrying a floxed exon in the BMP receptor 1A gene, we determined the hepatic gene expressions and proliferative activity following CCl4-treated liver.
Results.
We observed retardation of the healing response in the knockout mice treated with CCl4, including aggravated histological feature and reduced expressions of the albumin and Tdo2 genes, and a particular decrease in the proliferative activity shown by Ki-67 immunohistochemistry.
Conclusion.
Our findings suggest a crucial role of BMP signaling in the amelioration of acute liver injury.
American Psychological Association (APA)
Oumi, Nao& Taniguchi, Kumiko Amano& Kanai, Ayumi Miyashita& Yasunaga, Mayu& Nakanishi, Tomoko& Sato, Kenzo. 2012. A Crucial Role of Bone Morphogenetic Protein Signaling in the Wound Healing Response in Acute Liver Injury Induced by Carbon Tetrachloride. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474661
Modern Language Association (MLA)
Oumi, Nao…[et al.]. A Crucial Role of Bone Morphogenetic Protein Signaling in the Wound Healing Response in Acute Liver Injury Induced by Carbon Tetrachloride. International Journal of Hepatology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-474661
American Medical Association (AMA)
Oumi, Nao& Taniguchi, Kumiko Amano& Kanai, Ayumi Miyashita& Yasunaga, Mayu& Nakanishi, Tomoko& Sato, Kenzo. A Crucial Role of Bone Morphogenetic Protein Signaling in the Wound Healing Response in Acute Liver Injury Induced by Carbon Tetrachloride. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-474661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474661
