Anthrax Lethal Toxin Inhibits the Production of Proinflammatory Cytokines
Joint Authors
Li, Lydia Yue
Alibek, Ken
Alibek, Darya
Shiloach, Joseph
Wu, Aiguo
Bradburne, Christopher
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Biology
Medicine
Abstract EN
In previous studies, we have found that anthrax lethal toxin (LeTx) induces apoptosis in both murine macrophages and human peripheral blood mononuclear cells (PBMCs).
In this study, we further report that bacterial cell wall (CW) components of Bacillus (B.) anthracis are powerful inducers of proinflammatory cytokines from the PBMCs.
These effects are deprived when the LeTx is present.
The major causative element for this suppression is lethal factor (LF) rather than protective antigen (PA).
These results indicate that the roles of LeTx in anthrax pathogenesis, particularly its effects on cytokine production, should be reevaluated as our findings and other reports are controversial to the conventional concept.
American Psychological Association (APA)
Wu, Aiguo& Shiloach, Joseph& Alibek, Darya& Li, Lydia Yue& Bradburne, Christopher& Alibek, Ken. 2013. Anthrax Lethal Toxin Inhibits the Production of Proinflammatory Cytokines. Journal of Toxins،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-474672
Modern Language Association (MLA)
Wu, Aiguo…[et al.]. Anthrax Lethal Toxin Inhibits the Production of Proinflammatory Cytokines. Journal of Toxins No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-474672
American Medical Association (AMA)
Wu, Aiguo& Shiloach, Joseph& Alibek, Darya& Li, Lydia Yue& Bradburne, Christopher& Alibek, Ken. Anthrax Lethal Toxin Inhibits the Production of Proinflammatory Cytokines. Journal of Toxins. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-474672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474672