EGFR : A Master Piece in G1S Phase Transition of Liver Regeneration
Joint Authors
Collin de l'Hortet, Alexandra
Guidotti, Jacques-Emmanuel
Gilgenkrantz, Hélène
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy.
The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery.
During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle.
The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression.
Two growth factor receptors, c-Met and EGFR, tightly drive this transition.
Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper.
We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation.
Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies.
American Psychological Association (APA)
Collin de l'Hortet, Alexandra& Gilgenkrantz, Hélène& Guidotti, Jacques-Emmanuel. 2012. EGFR : A Master Piece in G1S Phase Transition of Liver Regeneration. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474673
Modern Language Association (MLA)
Collin de l'Hortet, Alexandra…[et al.]. EGFR : A Master Piece in G1S Phase Transition of Liver Regeneration. International Journal of Hepatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-474673
American Medical Association (AMA)
Collin de l'Hortet, Alexandra& Gilgenkrantz, Hélène& Guidotti, Jacques-Emmanuel. EGFR : A Master Piece in G1S Phase Transition of Liver Regeneration. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-474673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474673