Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice
Joint Authors
Chang, Heng-Yuan
Huang, Guan-Jhong
Yang, Chun-Hung
Huang, Shyh-Shyun
Peng, Wen-Huang
Chang, Yuan Shiun
Sheu, Ming-Jyh
Lu, Tsung-Chun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hispolon, an active ingredient in the fungi Phellinus linteus was evaluated with analgesic and anti-inflammatory effects.
Treatment of male ICR mice with hispolon (10 and 20 mg/kg) significantly inhibited the numbers of acetic acid-induced writhing response.
Also, our result showed that hispolon (20 mg/kg) significantly inhibited the formalin-induced pain in the later phase (P<.01).
In the anti-inflammatory test, hispolon (20 mg/kg) decreased the paw edema at the fourth and fifth hour after λ-carrageenin (Carr) administration, and increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver tissue.
We also demonstrated that hispolon significantly attenuated the malondialdehyde (MDA) level in the edema paw at the fifth hour after Carr injection.
Hispolon (10 and 20 mg/kg) decreased the nitric oxide (NO) levels on both the edema paw and serum level at the fifth hour after Carr injection.
Also, hispolon (10 and 20 mg/kg) diminished the serum TNF-α at the fifth hour after Carr injection.
The anti-inflammatory mechanisms of hispolon might be related to the decrease in the level of MDA in the edema paw by increasing the activities of SOD, GPx and GRx in the liver.
It probably exerts anti-inflammatory effects through the suppression of TNF-α and NO.
American Psychological Association (APA)
Chang, Heng-Yuan& Sheu, Ming-Jyh& Yang, Chun-Hung& Lu, Tsung-Chun& Chang, Yuan Shiun& Peng, Wen-Huang…[et al.]. 2010. Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-474701
Modern Language Association (MLA)
Chang, Heng-Yuan…[et al.]. Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-474701
American Medical Association (AMA)
Chang, Heng-Yuan& Sheu, Ming-Jyh& Yang, Chun-Hung& Lu, Tsung-Chun& Chang, Yuan Shiun& Peng, Wen-Huang…[et al.]. Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-474701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474701